An Echinococcus multilocularis coproantigen is a surface glycoprotein with unique O-gycosylation
نویسندگان
چکیده
منابع مشابه
A major Echinococcus multilocularis antigen is a mucin-type glycoprotein.
The metacestode of Echinococcus multilocularis is surrounded by a carbohydrate-rich laminated layer, which plays a key role in the establishment of the infection in the mammalian host. A major component of the laminated layer is an antigen referred to as Em2(G11). This highly species-specific antigen has been used for serodiagnoses of alveolar echinococcosis and is suggested to contain carbohyd...
متن کاملCharacterization of a Surface Glycoprotein from Echinococcus multilocularis and Its Mucosal Vaccine Potential in Dogs
Alveolar echinococcosis is a refractory disease caused by the metacestode stage of Echinococcus multilocularis. The life cycle of this parasite is maintained primarily between foxes and many species of rodents; thus, dogs are thought to be a minor definitive host except in some endemic areas. However, dogs are highly susceptible to E. multilocularis infection. Because of the close contact betwe...
متن کاملMonitoring of Echinococcus multilocularis infection in red foxes in Shiretoko, Japan, by coproantigen detection.
The study was conducted to evaluate a mAb-based coproantigen detection assay for monitoring fox prevalence of Echinococcus multilocularis infections in the Shiretoko National Park in Hokkaido, Japan. Eight fox families, each consisting of 2-4 adults and their pups, were selected because their territories have been determined. Faeces of each family (total n = 537) were collected monthly from Apr...
متن کاملEchinococcus multilocularis coproantigen detection by enzyme-linked immunosorbent assay in fox, dog, and cat populations.
A sandwich enzyme-linked immunosorbent assay (ELISA) for the detection of Echinococcus multilocularis coproantigens (EM-ELISA) was developed with polyclonal rabbit (solid phase) and chicken egg (catching) antibodies that were directed against E. multilocularis coproantigens and somatic worm antigens, respectively. In experimentally infected dogs and cats, coproantigens were first detectable 6-1...
متن کاملEchinococcus multilocularis in Estonia
To the Editor: Alveolar echinoco-ccosis (AE) caused by Echinococcus multilocularis is one of the most important emerging zoonosis in Europe. The fatality rate is >90% in untreated patients (1). In Europe, the distribution range of the zoonotic tapeworm E. multilocularis has expanded over the last few decades, and the parasite attracts increasing awareness as a public health issue (2–5). In 2003...
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ژورنال
عنوان ژورنال: Glycobiology
سال: 2009
ISSN: 0959-6658,1460-2423
DOI: 10.1093/glycob/cwp155